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dc.contributor.authorSewwandi, A.A.M.-
dc.contributor.authorSoysa, H.-
dc.contributor.authorSasimali, M.-
dc.date.accessioned2022-01-07T06:48:23Z-
dc.date.available2022-01-07T06:48:23Z-
dc.date.issued2021-03-26-
dc.identifier.citationSewwandi, A.A.M., Soysa,and H. Sasimali M. (2020). Electrochemical Evaluation of Delayed Release Behaviour of Diclofenac Sodium Tablets. Proceedings of SLIIT International Conference on Advancements in Sciences & Humanities.en_US
dc.identifier.urihttp://localhost:80/handle/123456789/506-
dc.description.abstractDiclofenac Sodium is a commonly used electro active anti-inflammatory drug. There are various analytical techniques to detect Diclofenac Sodium active ingredient including cyclic voltammetry. Cyclic voltammetry was used with different kinds of modified electrodes. In this project, drug release action of Diclofenac Sodium is detected by introducing bare Platinum electrode as the working electrode instead of the modified electrodes. Carbon and silver/silver chloride electrodes are counting and reference electrodes respectively. Platinum electrode is characterized by using 0.5 mM potassium ferrocyanide in a 0.1 M Potassium chloride solution at different scan rates. Diclofenac Sodium dissolution medium is a phosphate buffer solution. The optimum pH value of the phosphate buffer solution for the Diclofenac Sodium dissolution is identified as 6.8. From the resultant cyclic voltammograms of current density at bare platinum electrode Vs. applied potential, the variation of drug concentration with respect to the time is analyzed. The limit of detection (LOD) of Diclofenac Sodium and the limit on quantification (LOQ) on the bare platinum electrode are 0.21 mM and 0.63 mM respectively. The limit of detection is suitable to detect the delayed release behaviour of Diclofenac Sodium. All the three selected brands take around 12 hours to reach a constant concentration. Finally, the characteristic drug release curve of delayed release drugs can be obtained from the resultant graphs of drug concentration Vs. drug dissolution time for the three selected brands. Electrochemical sensors are therefore proposed as an alternative tool for delayed release analysis in medical sciences and pharmaceutical industries.en_US
dc.language.isoenen_US
dc.publisherFaculty of Humanities and Sciences - SLIITen_US
dc.relation.ispartofseriesSICASH 2020;34-39p-
dc.subjectDiclofenac Sodiumen_US
dc.subjectDelayed releaseen_US
dc.subjectPlatinumen_US
dc.subjectCyclic voltammetryen_US
dc.subjectCyclicvoltammogramen_US
dc.titleElectrochemical Evaluation of Delayed Release Behaviour of Diclofenac Sodium Tabletsen_US
dc.typeArticleen_US
Appears in Collections:Proceedings of the SLIIT International Conference on Advancements in Sciences and Humanities2020 [SICASH]

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